{"id":353193,"date":"2016-04-04T10:46:59","date_gmt":"2016-04-04T15:46:59","guid":{"rendered":"https:\/\/content.findlaw-admin.com\/ability-law\/injury\/product-liability\/actos-side-effects-faqs.html"},"modified":"2023-11-29T09:20:37","modified_gmt":"2023-11-29T14:20:37","slug":"actos-side-effects-faqs","status":"publish","type":"page","link":"https:\/\/www.findlaw.com\/injury\/product-liability\/actos-side-effects-faqs.html","title":{"rendered":"Actos Side Effects and Litigation"},"content":{"rendered":"\n<div class=\"wp-container-core-columns-is-layout-9d6595d7 fl-sectionWithSidebar fl-container fl-flex fl-flex-wrap fl-gap30\">\n<div class=\"fl-page-articles fl-section-main fl-section-main-full-width\"><h1 class=\"fl-no-margin-top\">Actos Side Effects and Litigation<\/h1>\n\n<section class=\"fl-gutenberg-byline\">\n    <div class=\"fl-gutenberg-byline-content\">\n                    By <a href=\"https:\/\/www.findlaw.com\/company\/our-team\/christie-nicholson-j-d\/\">Christie Nicholson, J.D.<\/a> | Legally reviewed by <a\n                href=\"https:\/\/www.findlaw.com\/company\/our-team\/oni-harton-j-d\/\">Oni Harton, J.D.<\/a>\n                | Last updated\n        <time>\n                            November 29, 2023\n                    <\/time>\n    <\/div>\n\n    \n    <details class=\"fl-gutenberg-byline-toggle fl-gutenberg-byline-legally-reviewed\">\n        <summary>\n            <i class=\"fl-gutenberg-byline-icon\" aria-hidden=\"true\"><\/i>\n            Legally Reviewed\n        <\/summary>\n\n        <div class=\"fl-gutenberg-byline-toggle-content\">\n            <p><em>This article has been written and reviewed for legal accuracy, clarity, and style by <a href=\"https:\/\/www.findlaw.com\/company\/our-team.html\">FindLaw\u2019s team of legal writers and attorneys<\/a> and in accordance with <a href=\"https:\/\/www.findlaw.com\/company\/company-history\/editorial-policy.html\">our editorial standards<\/a>.<\/em><\/p>\n\n        <\/div>\n    <\/details>\n\n    <details class=\"fl-gutenberg-byline-toggle fl-gutenberg-byline-fast-checked\">\n        <summary>\n            <i class=\"fl-gutenberg-byline-icon\" aria-hidden=\"true\"><\/i>\n            Fact-Checked\n        <\/summary>\n\n        <div class=\"fl-gutenberg-byline-toggle-content\">\n            <p><em>The last updated date refers to the last time this article was reviewed by FindLaw or one of our <a href=\"https:\/\/www.findlaw.com\/company\/our-team\/contributing-authors.html\">contributing authors<\/a>. We make every effort to keep our articles updated. For information regarding a specific legal issue affecting you, please <a href=\"https:\/\/lawyers.findlaw.com\/?fli=bylinelink\" target=\"_blank\" rel=\"noopener\">contact an attorney in your area<\/a>.<\/em><\/p>\n\n        <\/div>\n    <\/details>\n<\/section>\n\n\n    <div class=\"fl-callout-text article-blockquote\">\n        <div data-testid=\"loading-message\" data-fui-focus-visible=\"\">\n<div>\n<div id=\"chatMessageResponser2e\" class=\"___1yop6mf f336tjw f9ijwd5 fz7g6wx fod5ikn f1s184ao\" aria-live=\"assertive\">\n<div class=\"___1j4t0a1 f1lmfglv f1abmfm4\" aria-hidden=\"false\" data-testid=\"markdown-reply\" data-message-type=\"Chat\">\n<div class=\"___stpibi0 f22iagw f1vx9l62 fk15e71 f1k953kz f137keqj f1rncccw f1stllg3 f1w4kmmc f1tric3v f10dk5ic fx8cdsv f16nlwsl f1eookvz fhjrts3 fqugt2f f10km5jb f18d18k8 f1v1vhmp f1hdmul3 f198vjnp f2dshw1 fjpjndq fnmj2pj ffrrb40 f1mon110 fhajzam fimndk6 fxv4dng fb1rn9k f59wlhv f1xmfh30 f18yf5o5 fmr6chf fw8qy2q ff161sd f1qr7t77 f1yyogn1 foogchg fp5872b f1tpb8gf f1hdgrc8 f1vatr43 frkxccd f9pdzkb f158oiaz ft5kggy f5l4ui7 f13j03li f18xdoka f8off4e f1go6zfc f128n2ra f1jpxw2j f1lwd9n0 fy0b8hm f1g2633v fx4kvgi fkvolse f1gxrt3a f1os76ua f1js9cnw f1g87ej0 freluf8 f1yggaq6 f2i3chp f1151osp florpoh f35kzfz ftp9m57 f1e288vi fz62hnz fixvuys f1nmofwh fc1c6mv f18a2er7 fhvkrdl fhxnn68 f1oce4bo fvhlfan f7tc0t0 f1ngf1n2 ffrzq6x f1yjiq2m f1aqdgql f1huvaf f10ij78l f1k94sa4 fkmfumq f1jvzkyl f1eu24ob f1xbfc1f fmf0lwf f107dsy8 f3w566c f4648sl f13zpkng f7unjfp f8p1rz fzu6h1w f1i1bi6h f1smo7hi f1sk1xod f1kgogdq f1gjktkp ft608jz f19dd9cz fg3xr24 fhd155k f1b8gl2e fg4b9ou flb4lo fdicbfk fgwcyh1 f1jbds0d f1fb9uea f1stuka4 fcrtu6g fwqh0xn f11w66yg f6e0e65 f1vvgu0 f1607507 f1m9bycv f1ntoah8 f1b694rt faql4r2 fpjuhzh fmavl6h\">\n<p>Actos has been linked to serious side effects, including heart failure and bladder cancer. These risks led to thousands of lawsuits alleging the company failed to adequately warn patients and healthcare providers. Although the manufacturer settled federal cases for $2.4 billion, litigation continues in state courts.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<\/div>\n<\/div>\n\n    <\/div>\n\n\n\n<p>Actos (pioglitazone) is a popular Type 2 diabetes medication. The U.S. Food and Drug Administration (FDA) approved the drug in 1999.<\/p>\n<p>Takeda Pharmaceuticals manufactures this medication, which enjoyed early financial success. However, Takeda&#8217;s\u00a0<a href=\"https:\/\/www.uspharmacist.com\/article\/drug-patent-expirations-and-the-patent-cliff\" target=\"_blank\" rel=\"noopener\">patent on Actos expired in 2012<\/a>. This fact, along with negative publicity about the drug&#8217;s serious side effects, led to a decline in sales.<\/p>\n<p>This article explains the side effects of Actos. It also discusses state and federal lawsuits plaintiffs filed against both Takeda and the co-manufacturer of the diabetes drug, Eli Lilly and Company. While the multi-district litigation (MDL) against the pharmaceutical company closed in April 2018, plaintiffs have sued Takeda Pharmaceuticals and Eli Lilly for injuries caused by other drugs.<\/p>\n<p>If you have developed cancer or another illness after using Actos, you may have a legal claim. A <a href=\"https:\/\/lawyers.findlaw.com\/products-liability-law\/\" target=\"_blank\" rel=\"noopener\">product liability attorney<\/a> near you can evaluate your situation and determine if you have a valid case. If so, they will advocate for you throughout the process and fight for fair compensation.<\/p>\n<h2>What Is Diabetes?<\/h2>\n<p>Diabetes is a common disease characterized by the human body&#8217;s struggle to produce and absorb insulin. By far, the most common form is <a href=\"https:\/\/www.cdc.gov\/diabetes\/about\/about-type-2-diabetes.html\" target=\"_blank\" rel=\"noopener\">type 2 diabetes<\/a>, affecting 90% to 95% of the 38 million Americans with diabetes. Its chief characteristic is high blood sugar levels.<\/p>\n<p>There is no cure for diabetes, and the disease can lead to serious health problems. However, it&#8217;s treatable. Regularly monitoring blood sugar levels is essential to managing the disease. Most patients can rely on diet and exercise to control their blood sugar levels and live happy lives.<\/p>\n<p>Diabetes medications such as Actos may also be able to lower blood sugar levels.<\/p>\n<h2>Serious Side Effects of Actos<\/h2>\n<p>Before we discuss the possible side effects of Actos, it&#8217;s important to point out that people with <a href=\"https:\/\/diabetes.org\/about-diabetes\/type-1\" target=\"_blank\" rel=\"noopener\">type 1 diabetes<\/a> should not take this medication. People take the drug to treat type 2 diabetes.<\/p>\n<p>Like\u00a0<a href=\"https:\/\/www.findlaw.com\/injury\/product-liability\/dangerous-drugs.html\">most drugs<\/a>, there are potential side effects of taking the prescription drug. Many of these are minor and don&#8217;t cause any permanent health risks. However, there are also severe side effects that can lead to long-term injuries and even death.<\/p>\n<p>Some of the common side effects of Actos include:<\/p>\n<ul>\n<li>Headache<\/li>\n<li>Upper respiratory infection<\/li>\n<li>Weight gain<\/li>\n<li>Muscle pain<\/li>\n<li>Sinus infections<\/li>\n<li>Sore throat<\/li>\n<li>Trouble breathing<\/li>\n<li>Shortness of breath<\/li>\n<\/ul>\n<p>The side effects most patients worry about are the severe side effects. According to <a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/pioglitazone-oral-route\/side-effects\/DRG-20065503?p=1\" target=\"_blank\" rel=\"noopener\">Mayo Clinic<\/a>, some of the more\u00a0serious adverse events associated with the drug Actos include:<\/p>\n<ul>\n<li>Hypoglycemia<\/li>\n<li>Bone fractures<\/li>\n<li>Congestive heart failure<\/li>\n<li>Bladder cancer<\/li>\n<li>Liver damage or failure<\/li>\n<li>Low blood sugar<\/li>\n<li><a href=\"https:\/\/www.aao.org\/eye-health\/diseases\/what-is-macular-edema\" target=\"_blank\" rel=\"noopener\">Macular edema<\/a><\/li>\n<li>Heart attack<\/li>\n<li>Increased risk of heart disease<\/li>\n<\/ul>\n<p>If you or your loved one suffers any of these health issues after taking Actos, contact a <a href=\"https:\/\/lawyers.findlaw.com\/personal-injury-plaintiff\/\" target=\"_blank\" rel=\"noopener\">personal injury lawyer<\/a> immediately. You may have a claim for damages like thousands of other patients.<\/p>\n<h2>Actos and Heart Failure<\/h2>\n<p>In 2007, the FDA determined that the thiazolidinedione (TZD) class of diabetes medications, which includes Actos, may cause heart failure in some patients. Specifically, the drug increases a patient&#8217;s risk of congestive heart failure.<\/p>\n<p>The FDA required that Takeda place a\u00a0<a href=\"https:\/\/www.aafp.org\/pubs\/afp\/issues\/2010\/0201\/p298.html\" target=\"_blank\" rel=\"noopener\">black box warning<\/a>, the FDA&#8217;s strongest warning, on Actos labeling to alert consumers of the\u00a0<a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2007\/021073s031lbl.pdf\" target=\"_blank\" rel=\"noopener\">increased risk for heart failure<\/a>.<\/p>\n<h2>Actos and Bladder Cancer<\/h2>\n<p>Many\u00a0Actos patients sued Takeda\u00a0and Eli Lilly after developing bladder cancer. In 2011, the FDA announced that long-term use of Actos\u00a0<a href=\"http:\/\/www.fda.gov\/drugs\/drugsafety\/ucm259150.htm\" target=\"_blank\" rel=\"noopener\">may be associated with an increased risk of bladder cancer<\/a>. The FDA approved the risk information on Actos labeling after carefully reviewing a ten-year-long medical study on Actos.<\/p>\n<p>The study revealed that patients with greater exposure to Actos faced an increased risk of bladder cancer. Consequently, the FDA advised healthcare professionals to avoid prescribing Actos to patients with bladder cancer or a history of bladder cancer.<\/p>\n<h2>Drug Manufacturer Legal Liability<\/h2>\n<p>Many Actos users filed product liability lawsuits against Takeda. Under product liability law, manufacturers and sellers must ensure that the products they market are <a href=\"https:\/\/www.findlaw.com\/injury\/product-liability\/what-is-product-liability.html\">free from unreasonable defects or dangers<\/a>. The difficulty with prescription drugs is that many of them have inherent risks.<\/p>\n<p>Plaintiffs in the Actos lawsuits claimed that the defendant failed to warn them of the risks associated with Actos. Specifically, they argued that Actos caused bladder cancer, macular edema, and heart disease.<\/p>\n<p>Takeda should have warned patients and healthcare providers of the risks of Actos. But instead they hid internal communications that confirmed the risks. So many plaintiffs sued the drugmaker that the federal government consolidated the lawsuits into one MDL action. A judge for the Western District of Louisiana oversaw the <a href=\"https:\/\/caselaw.findlaw.com\/court\/us-jud-pan-mul-lit\/202106\" target=\"_blank\" rel=\"noopener\">multidistrict litigation (MDL)<\/a>.<\/p>\n<p>Takeda and their co-defendant, Eli Lilly, settled the federal cases for $2.4 billion. Each plaintiff received an average of $200,000. While the company agreed to settle, Takeda remained steadfast that their drug did not cause bladder cancer. On April 11, 2018, the court deemed the cases resolved and closed the MDL.<\/p>\n<p>Many plaintiffs also sued the drug manufacturer in state court. Takeda fared much better in state court. The defendant managed to get many of the verdicts against them <a href=\"https:\/\/www.findlaw.com\/litigation\/filing-a-lawsuit\/appealing-a-court-decision-or-judgment.html\">overturned on appeal<\/a>.<\/p>\n<h2>Get Legal Help With an Actos Injury or Illness<\/h2>\n<p>If you or a family member takes a type 2 diabetes medication and develops an illness, you may have a legal claim. The best thing to do is talk to a <a href=\"https:\/\/lawyers.findlaw.com\/products-liability-law\/\" target=\"_blank\" rel=\"noopener\">product liability lawyer<\/a> near you. They can review your claim and advise on how to best proceed to protect your rights and seek compensation.<\/p>\n<p>FindLaw&#8217;s directory of <a href=\"https:\/\/lawyers.findlaw.com\/products-liability-law\/\" target=\"_blank\" rel=\"noopener\">product liability attorneys<\/a> can get you started. Select your state or city to review contact and ratings information for local experts. Your search results will also link you to additional details about the attorneys\u2019 experience with dangerous drug cases.<\/p>\n\n\n<div class=\"was-this-helpful\">\n    <div\n            class=\"was-this-helpful__question-container\"\n            aria-labelledby=\"was-this-helpful__question\"\n            role=\"group\"\n    >\n        <span\n                id=\"was-this-helpful__question\"\n                class=\"was-this-helpful__question fl-text-lg-bold\"\n        >Was this helpful?<\/span>\n        <button\n                class=\"was-this-helpful__button fl-text-sm\"\n                aria-label=\"Yes\"\n                value=\"yes\"\n        >\n            <span class=\"was-this-helpful__button-text fl-text-bold\">Yes<\/span>\n            <i class=\"was-this-helpful__button-icon\">\n                <svg width=\"22\" height=\"22\" viewBox=\"0 0 22 22\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                    <g id=\"thumbs-up\" 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  class=\"fa fa-angle-right medium\"\n                        aria-hidden=\"true\"\n                    ><\/i>\n                <\/button>\n                <button\n                    class=\"was-this-helpful__feedback-button was-this-helpful__feedback-button--cancel fl-button primary disabled\"\n                    type=\"reset\"\n                >\n                    <span class=\"fl-button-content\">Cancel<\/span>\n                    <i\n                        class=\"fa fa-times-circle medium\"\n                        aria-hidden=\"true\"\n                    ><\/i>\n                <\/button>\n            <\/div>\n        <\/form>\n    <\/div>\n    <div class=\"was-this-helpful__thank-you-message\" role=\"status\">\n        <i class=\"was-this-helpful__thank-you-message-icon fa fa-check\"><\/i>\n        <p class=\"was-this-helpful__thank-you-message-text\" aria-live=\"polite\"><\/p>\n    <\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"fl-section-sidebar\"><div class=\"fl-editors-summary\" data-testid=\"fl-editors-summary\">\n    \n    <div class=\"fl-editors-summary-content\" data-testid=\"fl-editors-summary-content\">\n                    <h2>Can I Solve This on My Own or Do I Need an Attorney?<\/h2>\n                <div class=\"fl-editors-summary-content-main\" data-testid=\"fl-editors-summary-content-main\">\n            \n        <\/div>\n        <ul class=\"fl-list-style-none\">\n                            <li data-testid=\"fl-editors-summary-content-item\">\n                    <i class=\"fa fa-check medium fl-editors-summary-content-item-icon\" aria-hidden=\"true\"><\/i>\n                    A lawyer can help seek fair compensation on your behalf\n\n                <\/li>\n                            <li data-testid=\"fl-editors-summary-content-item\">\n                    <i class=\"fa fa-check medium fl-editors-summary-content-item-icon\" aria-hidden=\"true\"><\/i>\n                    Drug manufacturers have teams of lawyers on their side to defend against lawsuits\n\n                <\/li>\n                            <li data-testid=\"fl-editors-summary-content-item\">\n                    <i class=\"fa fa-check medium fl-editors-summary-content-item-icon\" aria-hidden=\"true\"><\/i>\n                    An attorney can help gather documentation and evidence to support your claim\n\n                <\/li>\n                    <\/ul>\n                    <div class=\"fl-editors-summary-content-description\" data-testid=\"fl-editors-summary-content-description\">\n                <p>An experienced attorney can increase your chances of success with your case. 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