{"id":353277,"date":"2016-04-04T10:46:47","date_gmt":"2016-04-04T15:46:47","guid":{"rendered":"https:\/\/content.findlaw-admin.com\/ability-law\/injury\/product-liability\/gleevec.html"},"modified":"2024-01-26T12:02:54","modified_gmt":"2024-01-26T17:02:54","slug":"gleevec","status":"publish","type":"page","link":"https:\/\/www.findlaw.com\/injury\/product-liability\/gleevec.html","title":{"rendered":"Gleevec Overview: Uses and Risks"},"content":{"rendered":"\n<div class=\"wp-container-core-columns-is-layout-9d6595d7 fl-sectionWithSidebar fl-container fl-flex fl-flex-wrap fl-gap30\">\n<div class=\"fl-page-articles fl-section-main fl-section-main-full-width\"><h1 class=\"fl-no-margin-top\">Gleevec Overview: Uses and Risks<\/h1>\n\n<section class=\"fl-gutenberg-byline\">\n    <div class=\"fl-gutenberg-byline-content\">\n                    By <a href=\"https:\/\/www.findlaw.com\/company\/our-team\/christie-nicholson-j-d\/\">Christie Nicholson, J.D.<\/a> | Legally reviewed by <a\n                href=\"https:\/\/www.findlaw.com\/company\/our-team\/oni-harton-j-d\/\">Oni Harton, J.D.<\/a>\n                | Last updated\n        <time>\n                            January 26, 2024\n                    <\/time>\n    <\/div>\n\n    \n    <details class=\"fl-gutenberg-byline-toggle fl-gutenberg-byline-legally-reviewed\">\n        <summary>\n            <i class=\"fl-gutenberg-byline-icon\" aria-hidden=\"true\"><\/i>\n            Legally Reviewed\n        <\/summary>\n\n        <div class=\"fl-gutenberg-byline-toggle-content\">\n            <p><em>This article has been written and reviewed for legal accuracy, clarity, and style by <a href=\"https:\/\/www.findlaw.com\/company\/our-team.html\">FindLaw\u2019s team of legal writers and attorneys<\/a> and in accordance with <a href=\"https:\/\/www.findlaw.com\/company\/company-history\/editorial-policy.html\">our editorial standards<\/a>.<\/em><\/p>\n\n        <\/div>\n    <\/details>\n\n    <details class=\"fl-gutenberg-byline-toggle fl-gutenberg-byline-fast-checked\">\n        <summary>\n            <i class=\"fl-gutenberg-byline-icon\" aria-hidden=\"true\"><\/i>\n            Fact-Checked\n        <\/summary>\n\n        <div class=\"fl-gutenberg-byline-toggle-content\">\n            <p><em>The last updated date refers to the last time this article was reviewed by FindLaw or one of our <a href=\"https:\/\/www.findlaw.com\/company\/our-team\/contributing-authors.html\">contributing authors<\/a>. We make every effort to keep our articles updated. For information regarding a specific legal issue affecting you, please <a href=\"https:\/\/lawyers.findlaw.com\/?fli=bylinelink\" target=\"_blank\" rel=\"noopener\">contact an attorney in your area<\/a>.<\/em><\/p>\n\n        <\/div>\n    <\/details>\n<\/section>\n\n\n    <div class=\"fl-callout-text article-blockquote\">\n        <div data-testid=\"loading-message\">\n<div>\n<div id=\"chatMessageResponser2i\" class=\"___1yop6mf f336tjw f9ijwd5 fz7g6wx fod5ikn f1s184ao\" aria-live=\"assertive\">\n<div class=\"___1j4t0a1 f1lmfglv f1abmfm4\" aria-hidden=\"false\" data-testid=\"markdown-reply\" data-message-type=\"Chat\">\n<div class=\"___stpibi0 f22iagw f1vx9l62 fk15e71 f1k953kz f137keqj f1rncccw f1stllg3 f1w4kmmc f1tric3v f10dk5ic fx8cdsv f16nlwsl f1eookvz fhjrts3 fqugt2f f10km5jb f18d18k8 f1v1vhmp f1hdmul3 f198vjnp f2dshw1 fjpjndq fnmj2pj ffrrb40 f1mon110 fhajzam fimndk6 fxv4dng fb1rn9k f59wlhv f1xmfh30 f18yf5o5 fmr6chf fw8qy2q ff161sd f1qr7t77 f1yyogn1 foogchg fp5872b f1tpb8gf f1hdgrc8 f1vatr43 frkxccd f9pdzkb f158oiaz ft5kggy f5l4ui7 f13j03li f18xdoka f8off4e f1go6zfc f128n2ra f1jpxw2j f1lwd9n0 fy0b8hm f1g2633v fx4kvgi fkvolse f1gxrt3a f1os76ua f1js9cnw f1g87ej0 freluf8 f1yggaq6 f2i3chp f1151osp florpoh f35kzfz ftp9m57 f1e288vi fz62hnz fixvuys f1nmofwh fc1c6mv f18a2er7 fhvkrdl fhxnn68 f1oce4bo fvhlfan f7tc0t0 f1ngf1n2 ffrzq6x f1yjiq2m f1aqdgql f1huvaf f10ij78l f1k94sa4 fkmfumq f1jvzkyl f1eu24ob f1xbfc1f fmf0lwf f107dsy8 f3w566c f4648sl f13zpkng f7unjfp f8p1rz fzu6h1w f1i1bi6h f1smo7hi f1sk1xod f1kgogdq f1gjktkp ft608jz f19dd9cz fg3xr24 fhd155k f1b8gl2e fg4b9ou flb4lo fdicbfk fgwcyh1 f1jbds0d f1fb9uea f1stuka4 fcrtu6g fwqh0xn f11w66yg f6e0e65 f1vvgu0 f1607507 f1m9bycv f1ntoah8 f1b694rt faql4r2 fpjuhzh fmavl6h\">\n<p>Gleevec (imatinib mesylate) is a prescription medication approved by the FDA to treat several cancers. While effective, it can cause side effects such as nausea, fluid retention, and lowered blood cell counts, which may increase the risk of infection or bleeding.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<\/div>\n<\/div>\n\n    <\/div>\n\n\n\n<p>Gleevec (imatinib mesylate) is the brand name for a prescription drug that doctors use to treat some cancers. Gleevec prevents cancer cells from growing. The U.S. Food and Drug Administration (FDA) approved\u00a0<a href=\"http:\/\/www.gleevec.com\/index.jsp\" target=\"_blank\" rel=\"noopener\">Gleevec<\/a>\u00a0in 2001 when Novartis submitted it for review.<\/p>\n<p>Two types of cancers Gleevec treats are chronic myeloid leukemia and gastrointestinal stromal tumors.<\/p>\n<p>This article discusses the side effects of Gleevec. It also explains what factors to consider when deciding whether to take Gleevec.<\/p>\n<p>If you have experienced significant health issues after using Gleevac, first talk to your doctor. Then, reach out to a <a href=\"https:\/\/lawyers.findlaw.com\/products-liability-law\/?\" target=\"_blank\" rel=\"noopener\">product liability attorney<\/a> near you to understand your legal rights and options.<\/p>\n<h2>Conditions Gleevec Treats<\/h2>\n<p>Oncologists and physicians prescribe Gleevec to patients with chronic myeloid leukemia (CML) or gastrointestinal stromal tumors (GIST).<\/p>\n<p>CML is a disease where the body makes too many abnormal white blood cells. As a result, people with CML get sick more often and feel weak and tired much of the time. Gleevec helps the body stop making these abnormal white blood cells.<\/p>\n<p>GIST is a group of cancer cells growing in the stomach, intestines, or rectum walls. Gleevec helps the body stop making these abnormal cells.<\/p>\n<p>Gleevec targets specific proteins in your body that help cancer cells grow. These proteins are tyrosine kinases or Bcr-Abl proteins. By preventing these proteins from assisting the growth of cancer cells, Gleevec can help prevent the spread of invasive cancers.<\/p>\n<p>In 2006, the\u00a0<a href=\"https:\/\/www.mpnresearchfoundation.org\/news\/gleevecr-approved-in-the-us-for-five-rare-life-threatening-disorders-with-limited-treatment-options\/\" target=\"_blank\" rel=\"noopener\">FDA approved<\/a>\u00a0the use of Gleevec for other diseases. These include specific cancers and blood diseases that respond to tyrosine kinase inhibitors.<\/p>\n<p>These new uses include:<\/p>\n<ul>\n<li>Relapsed\/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (PH+ ALL)<\/li>\n<li>Philadelphia chromosome positive chronic myeloid leukemia (PH+CML)<\/li>\n<li>Tumor lysis syndrome<\/li>\n<li>Chronic myelogenous leukemia<\/li>\n<li>Aggressive systemic mastocytosis<\/li>\n<li>Myelodysplastic and myeloproliferative diseases (MDS\/MPD)<\/li>\n<li>Chronic eosinophilic leukemia (CEL)<\/li>\n<li>Dermatofibrosarcoma protuberans (PDGFR)<\/li>\n<li>Hypereosinophilic syndrome (HES)<\/li>\n<\/ul>\n<p>There&#8217;s no need to try to memorize these medical terms. But you can check if any of these diseases match your diagnosis. If they do, then Gleevec may be an option for you.<\/p>\n<p>The FDA approved Gleevec for treating these diseases after reviewing the results of clinical trials at Novartis Oncology. The FDA has also approved the use of Gleevec to treat\u00a0<a href=\"https:\/\/www.verywellhealth.com\/unresectable-tumors-reasons-treatment-2249210\" target=\"_blank\" rel=\"noopener\">unresectable cancers<\/a>. These are cancers that your surgeon can&#8217;t completely remove from your body.<\/p>\n<h2>Talk to Your Healthcare Provider Before Taking Gleevec<\/h2>\n<p>Always talk to your healthcare professional before taking Gleevec. Certain conditions make taking this medication unsafe.<\/p>\n<p>Inform your oncologist if you suffer from any of the following:<\/p>\n<ul>\n<li>Unusual allergic reaction to Gleevec<\/li>\n<li>Other allergies (foods, preservatives, or dyes)<\/li>\n<li>Pregnancy (or if you are breastfeeding)<\/li>\n<li>Anemia<\/li>\n<li>Platelet problems<\/li>\n<li>White blood cell<\/li>\n<li>Chickenpox or Shingles<\/li>\n<li>Liver disease<\/li>\n<li>Any infections<\/li>\n<\/ul>\n<p>Always seek medical advice as you research cancer treatment.<\/p>\n<h2>Some People Should Not Use Gleevec<\/h2>\n<p>Women taking Gleevec should not try to get pregnant while taking the drug. People with anemia or low white blood cell counts should also avoid Gleevec. This is because the medication temporarily lowers the number of white blood cells in your blood, increasing your chance of getting an infection.<\/p>\n<p>Gleevec can also lower the number of platelets. Platelets are necessary for proper blood clotting. Talk to your healthcare professional about steps to reduce the risk of infection or bleeding.<\/p>\n<h2>Gleevec Side Effects<\/h2>\n<p>Almost all drugs have adverse side effects. The same is true for Gleevec.<\/p>\n<p>According to the Mayo Clinic, common\u00a0<a href=\"http:\/\/www.mayoclinic.org\/drugs-supplements\/imatinib-oral-route\/side-effects\/drg-20068331\" target=\"_blank\" rel=\"noopener\">side effects of Gleevec<\/a>\u00a0include:<\/p>\n<ul>\n<li>Nausea<\/li>\n<li>Vomiting<\/li>\n<li>Fluid retention<\/li>\n<li>Muscle cramps<\/li>\n<li>Skin rash<\/li>\n<li>Diarrhea<\/li>\n<li>Heartburn<\/li>\n<li>Loss of appetite<\/li>\n<li>Shortness of breath<\/li>\n<li>Joint pain<\/li>\n<li>Abdominal pain<\/li>\n<li>Bone pain<\/li>\n<li>Headache<\/li>\n<li>Serious side effects are uncommon but include:<\/li>\n<li>Severe fluid retention (edema)<\/li>\n<li>Liver problems<\/li>\n<li>Potential for bleeding (hemorrhage), especially in older adults<\/li>\n<\/ul>\n<p>Tell your healthcare professional if you experience swelling or weight gain from water retention.<\/p>\n<h2>Gleevec and Other Medications<\/h2>\n<p>Gleevec can interact with other medications, alcohol, or recreational drugs. Tell your doctor about all your medicines, including prescriptions, over-the-counter drugs, herbs, and supplements.<\/p>\n<p>Be sure to tell your healthcare professional if you take the following medications or foods. They can put you at a greater risk of side effects. The following medications and food may increase the amount of Gleevec in your blood:<\/p>\n<ul>\n<li>Ketoconazole<\/li>\n<li>Itraconazole<\/li>\n<li>Erythromycin<\/li>\n<li>Clarithromycin<\/li>\n<li>Nefazodone<\/li>\n<li>Indinavir<\/li>\n<li>Atazanavir<\/li>\n<li>Grapefruit<\/li>\n<li>Grapefruit juice<\/li>\n<li>Grapefruit-containing food or vitamins<\/li>\n<\/ul>\n<p>Conversely, other medications may decrease the amount of Gleevec in your blood. This decreases its effectiveness. These medications and supplements include:<\/p>\n<ul>\n<li>Dexamethasone<\/li>\n<li>Phenytoin<\/li>\n<li>Carbamazepine<\/li>\n<li>Rifampicin<\/li>\n<li>Phenobarbital<\/li>\n<li>St. John&#8217;s Wort<\/li>\n<\/ul>\n<h2>Preventing Infections While Using Gleevec<\/h2>\n<p>Gleevec can increase your risk of getting an infection. This is because it lowers your white blood cell count. So, you&#8217;ll want to be extra cautious while using Gleevec. Gleevec can also lower your platelet count, which decreases your blood&#8217;s ability to clot properly.<\/p>\n<p>To reduce the risk of infection or bleeding, you can take the\u00a0<a href=\"http:\/\/chemocare.com\/chemotherapy\/drug-info\/gleevec.aspx#.U-A4bfldWBQ\" target=\"_blank\" rel=\"noopener\">following precautions<\/a>:<\/p>\n<ul>\n<li>Avoid people with infections<\/li>\n<li>Check with your doctor immediately if you notice any unusual bleeding, bruising, or pinpoint red spots on your skin<\/li>\n<li>Be careful when using a regular toothbrush, dental floss, or toothpicks<\/li>\n<li>Avoid contact sports and situations where bruising or injury could occur<\/li>\n<\/ul>\n<p>Pay attention to your doctor&#8217;s instructions and read your medication guide. This will help you prevent infections and stay safe while taking Gleevec.<\/p>\n<h2>Research on Gleevec<\/h2>\n<p>Studies show that\u00a0<a href=\"https:\/\/ashpublications.org\/thehematologist\/article\/doi\/10.1182\/hem.V3.5.5991\/453159\/Gleevec-and-the-Heart\" target=\"_blank\" rel=\"noopener\">Gleevec can cause heart problems<\/a>. Researchers have also conducted\u00a0<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1609324\" target=\"_blank\" rel=\"noopener\">studies in patients with chronic myeloid leukemia (CML)<\/a>. But the overall cancer survival rate of CML patients using Gleevec is exceptionally high. So, while the reported rate of heart failure is low, many healthcare professionals say the benefits of Gleevec outweigh its risks.<\/p>\n<h2>Injured by Gleevac or Another Pharmaceutical? Get Legal Help<\/h2>\n<p>Most medications have side effects. But drugmakers must make their products as reasonably safe as possible. They must also inform the medical community and the public of their drugs&#8217; side effects and health risks.<\/p>\n<p>If a manufacturer fails to do so, it may be responsible for patients&#8217; injuries. This is especially true if patients get hurt due to inadequate warnings or by an\u00a0<a href=\"https:\/\/www.findlaw.com\/injury\/product-liability\/dangerous-drugs.html\">unreasonably dangerous drug<\/a>.<\/p>\n<p>Most patients who suffer an injury file a\u00a0<a href=\"https:\/\/www.findlaw.com\/injury\/product-liability\/what-is-product-liability.html\">product liability lawsuit<\/a>\u00a0against the drug manufacturer. Others file a medical malpractice lawsuit against their doctor. It all depends on the facts surrounding your case.<\/p>\n<p>If you or a loved one experiences dangerous symptoms or medical conditions while taking Gleevec, seek immediate medical attention. Talk to an experienced\u00a0<a href=\"https:\/\/lawyers.findlaw.com\/products-liability-law\/?fli=dcta\" target=\"_blank\" rel=\"noopener\">product liability attorney<\/a> to discuss your legal options.<\/p>\n\n\n<div class=\"was-this-helpful\">\n    <div\n            class=\"was-this-helpful__question-container\"\n            aria-labelledby=\"was-this-helpful__question\"\n            role=\"group\"\n    >\n        <span\n                id=\"was-this-helpful__question\"\n                class=\"was-this-helpful__question fl-text-lg-bold\"\n        >Was this helpful?<\/span>\n        <button\n                class=\"was-this-helpful__button fl-text-sm\"\n                aria-label=\"Yes\"\n                value=\"yes\"\n        >\n            <span class=\"was-this-helpful__button-text fl-text-bold\">Yes<\/span>\n            <i class=\"was-this-helpful__button-icon\">\n                <svg width=\"22\" height=\"22\" viewBox=\"0 0 22 22\" fill=\"none\" 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