{"id":353364,"date":"2016-04-04T10:46:52","date_gmt":"2016-04-04T15:46:52","guid":{"rendered":"https:\/\/content.findlaw-admin.com\/ability-law\/injury\/product-liability\/serzone.html"},"modified":"2024-02-09T14:09:55","modified_gmt":"2024-02-09T19:09:55","slug":"serzone","status":"publish","type":"page","link":"https:\/\/www.findlaw.com\/injury\/product-liability\/serzone.html","title":{"rendered":"Serzone and Nefazodone: Side Effects and Health Risks"},"content":{"rendered":"\n<div class=\"wp-container-core-columns-is-layout-9d6595d7 fl-sectionWithSidebar fl-container fl-flex fl-flex-wrap fl-gap30\">\n<div class=\"fl-page-articles fl-section-main fl-section-main-full-width\"><h1 class=\"fl-no-margin-top\">Serzone and Nefazodone: Side Effects and Health Risks<\/h1>\n\n<section class=\"fl-gutenberg-byline\">\n    <div class=\"fl-gutenberg-byline-content\">\n                    By <a href=\"https:\/\/www.findlaw.com\/company\/our-team\/christie-nicholson-j-d\/\">Christie Nicholson, J.D.<\/a> | Legally reviewed by <a\n                href=\"https:\/\/www.findlaw.com\/company\/our-team\/oni-harton-j-d\/\">Oni Harton, J.D.<\/a>\n                | Last reviewed\n        <time>\n                            February 09, 2024\n                    <\/time>\n    <\/div>\n\n    \n    <details class=\"fl-gutenberg-byline-toggle fl-gutenberg-byline-legally-reviewed\">\n        <summary>\n            <i class=\"fl-gutenberg-byline-icon\" aria-hidden=\"true\"><\/i>\n            Legally Reviewed\n        <\/summary>\n\n        <div class=\"fl-gutenberg-byline-toggle-content\">\n            <p><em>This article has been written and reviewed for legal accuracy, clarity, and style by <a href=\"https:\/\/www.findlaw.com\/company\/our-team.html\">FindLaw\u2019s team of legal writers and attorneys<\/a> and in accordance with <a href=\"https:\/\/www.findlaw.com\/company\/company-history\/editorial-policy.html\">our editorial standards<\/a>.<\/em><\/p>\n\n        <\/div>\n    <\/details>\n\n    <details class=\"fl-gutenberg-byline-toggle fl-gutenberg-byline-fast-checked\">\n        <summary>\n            <i class=\"fl-gutenberg-byline-icon\" aria-hidden=\"true\"><\/i>\n            Fact-Checked\n        <\/summary>\n\n        <div class=\"fl-gutenberg-byline-toggle-content\">\n            <p><em>The last updated date refers to the last time this article was reviewed by FindLaw or one of our <a href=\"https:\/\/www.findlaw.com\/company\/our-team\/contributing-authors.html\">contributing authors<\/a>. We make every effort to keep our articles updated. For information regarding a specific legal issue affecting you, please <a href=\"https:\/\/lawyers.findlaw.com\/?fli=bylinelink\" target=\"_blank\" rel=\"noopener\">contact an attorney in your area<\/a>.<\/em><\/p>\n\n        <\/div>\n    <\/details>\n<\/section>\n\n\n    <div class=\"fl-callout-text article-blockquote\">\n        <div data-testid=\"loading-message\">\n<div>\n<div id=\"chatMessageResponseron\" class=\"___1yop6mf f336tjw f9ijwd5 fz7g6wx fod5ikn f1s184ao\" aria-live=\"assertive\">\n<div class=\"___1j4t0a1 f1lmfglv f1abmfm4\" aria-hidden=\"false\" data-testid=\"markdown-reply\" data-message-type=\"Chat\">\n<div class=\"___stpibi0 f22iagw f1vx9l62 fk15e71 f1k953kz f137keqj f1rncccw f1stllg3 f1w4kmmc f1tric3v f10dk5ic fx8cdsv f16nlwsl f1eookvz fhjrts3 fqugt2f f10km5jb f18d18k8 f1v1vhmp f1hdmul3 f198vjnp f2dshw1 fjpjndq fnmj2pj ffrrb40 f1mon110 fhajzam fimndk6 fxv4dng fb1rn9k f59wlhv f1xmfh30 f18yf5o5 fmr6chf fw8qy2q ff161sd f1qr7t77 f1yyogn1 foogchg fp5872b f1tpb8gf f1hdgrc8 f1vatr43 frkxccd f9pdzkb f158oiaz ft5kggy f5l4ui7 f13j03li f18xdoka f8off4e f1go6zfc f128n2ra f1jpxw2j f1lwd9n0 fy0b8hm f1g2633v fx4kvgi fkvolse f1gxrt3a f1os76ua f1js9cnw f1g87ej0 freluf8 f1yggaq6 f2i3chp f1151osp florpoh f35kzfz ftp9m57 f1e288vi fz62hnz fixvuys f1nmofwh fc1c6mv f18a2er7 fhvkrdl fhxnn68 f1oce4bo fvhlfan f7tc0t0 f1ngf1n2 ffrzq6x f1yjiq2m f1aqdgql f1huvaf f10ij78l f1k94sa4 fkmfumq f1jvzkyl f1eu24ob f1xbfc1f fmf0lwf f107dsy8 f3w566c f4648sl f13zpkng f7unjfp f8p1rz fzu6h1w f1i1bi6h f1smo7hi f1sk1xod f1kgogdq f1gjktkp ft608jz f19dd9cz fg3xr24 fhd155k f1b8gl2e fg4b9ou flb4lo fdicbfk fgwcyh1 f1jbds0d f1fb9uea f1stuka4 fcrtu6g fwqh0xn f11w66yg f6e0e65 f1vvgu0 f1607507 f1m9bycv f1ntoah8 f1b694rt faql4r2 fpjuhzh fmavl6h\">\n<p>Serzone (nefazodone) was an antidepressant used to treat major depression and anxiety. It was withdrawn from the U.S. market in 2004. The drug faced scrutiny due to reports of severe liver damage and other serious side effects. Although the brand name is discontinued, the generic version remains available.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<\/div>\n<\/div>\n<div class=\"___r3ho0x0 fyxfkj9 f1w1vubc f1mpe4l3 f1jlpb2r f1a3p1vp f1mk8lai frkrog8 fz5stix\" aria-live=\"assertive\" data-testid=\"announced-message\"><\/div>\n\n    <\/div>\n\n\n\n<p>Serzone (nefazodone) is an antidepressant doctors use to treat major depression, anxiety, and related health disorders. Bristol-Myers Squibb Company manufactured the drug. The U.S. Food and Drug Administration (FDA) <a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2003\/020152_s031_SERZONETOC.cfm\" target=\"_blank\" rel=\"noopener\">approved it in 1994<\/a>.<\/p>\n<p>In 2001, worldwide sales of Serzone were around $409 million. However, on May 19th, 2004, Bristol-Myers Squibb announced it would <a href=\"https:\/\/www.findlaw.com\/injury\/product-liability\/why-drugs-get-pulled-from-the-market.html\">no longer sell the drug<\/a> in the U.S. due to declining sales. They had already taken the drug off the market in Australia, Europe, and Canada.<\/p>\n<p>The drugmaker stated it <a href=\"https:\/\/www.cbsnews.com\/news\/anti-depressant-taken-off-market\/\" target=\"_blank\" rel=\"noopener\">stopped selling the antidepressant<\/a> for business reasons. But some believe it was due to claims that Serzone caused liver failure.<\/p>\n<p>The generic version of Serzone (<a href=\"https:\/\/www.webmd.com\/drugs\/2\/drug-4286\/nefazodone-oral\/details\" target=\"_blank\" rel=\"noopener\">nefazodone hydrochloride<\/a>) is still available.\u00a0<a href=\"https:\/\/www.tevausa.com\/news-and-media\/press-releases\/teva-nefazodone-statement\/\" target=\"_blank\" rel=\"noopener\">Teva<\/a>\u00a0is the lone manufacturer of this drug.<\/p>\n<p>This article provides an overview of Serzone, including its side effects and health risks. You&#8217;ll also learn about your legal options if you or a loved one becomes sick after taking Serzone or nefazodone.<\/p>\n<p>Drug manufacturers have a legal responsibility to ensure their medications are safe to use and carry adequate warnings. If you&#8217;ve been harmed by Serzone or another drug, you have legal options. Contact a <a href=\"https:\/\/lawyers.findlaw.com\/products-liability-law\/\" target=\"_blank\" rel=\"noopener\">product liability attorney<\/a> near you to see if you have a valid claim. If so, your attorney will guide you through the legal process and fight for fair compensation.<\/p>\n<h2>Serzone and Potential Drug Interactions<\/h2>\n<p>Serzone is no longer available. But the generic version of the drug is still available. Doctors may prescribe the generic drug to patients with\u00a0<a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/symptoms-causes\/syc-20356007\" target=\"_blank\" rel=\"noopener\">major depressive disorder<\/a>.<\/p>\n<p>Avoid taking nefazodone if you take any of the following prescription drugs:<\/p>\n<ul>\n<li>Carbamazepine<\/li>\n<li>Trazodone<\/li>\n<li>Fluoxetine<\/li>\n<li>Astemizole<\/li>\n<li>Cisapride<\/li>\n<li>Pimozide<\/li>\n<li>Terfenadine<\/li>\n<\/ul>\n<p>Some of these drugs are no longer available. But you may still have some of them in your medicine cabinet.<\/p>\n<p>Before you take any prescription drug, you must seek medical advice. Your doctor will evaluate your charts to ensure there are no <a href=\"https:\/\/www.webmd.com\/interaction-checker\/default.htm\" target=\"_blank\" rel=\"noopener\">adverse drug interactions.<\/a> They can also confirm that you don&#8217;t have an allergic reaction to the new drug.<\/p>\n<p>Don&#8217;t automatically take another pill after a missed dose of Serzone (or the generic). Ask your doctor whether to wait for your next dose or double up. Always keep your prescription medications at room temperature and out of reach of children.<\/p>\n<h2>Side Effects of Serzone<\/h2>\n<p>Serzone chemically differs from\u00a0<a href=\"http:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/in-depth\/ssris\/art-20044825\" target=\"_blank\" rel=\"noopener\">selective serotonin reuptake inhibitor<\/a>\u00a0(SSRI) and\u00a0<a href=\"http:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/in-depth\/maois\/ART-20043992\" target=\"_blank\" rel=\"noopener\">monoamine oxidase inhibitor<\/a>\u00a0(MAOI) antidepressants. It inhibits serotonin and norepinephrine uptake and blocks one type of serotonin receptor.<\/p>\n<p>This blocking effect significantly decreases insomnia, weight gain, and lack of sexual interest that patients experience with other antidepressants. This doesn&#8217;t mean Serzone didn&#8217;t have adverse side effects.<\/p>\n<p>The most common\u00a0<a href=\"http:\/\/www.mayoclinic.org\/drugs-supplements\/nefazodone-oral-route\/side-effects\/drg-20065008\" target=\"_blank\" rel=\"noopener\">side effects of Serzone<\/a>\u00a0include:<\/p>\n<ul>\n<li>Dry mouth<\/li>\n<li>Nausea<\/li>\n<li>Drowsiness<\/li>\n<li>Dizziness<\/li>\n<li>Tiredness<\/li>\n<li>Constipation<\/li>\n<li>Weakness<\/li>\n<li>Hives<\/li>\n<li>Lightheadedness<\/li>\n<li>Blurred vision<\/li>\n<li>Confusion<\/li>\n<\/ul>\n<p>If you notice these symptoms worsening, seek immediate attention. You should also call your healthcare professional if you experience any of the following adverse effects:<\/p>\n<ul>\n<li>Jaundice<\/li>\n<li>Loss of appetite<\/li>\n<li>Abdominal pain<\/li>\n<li>Dark urine<\/li>\n<\/ul>\n<p>Patients with liver problems should not take Serzone or nefazodone. Pregnant women and women hoping to become pregnant should avoid Serzone. The same applies to women who are breastfeeding.<\/p>\n<h2>Serious Risks: Liver Damage<\/h2>\n<p>In December of 2001, the U.S. Food and Drug Administration (FDA) told Bristol-Myers Squibb Co. it must include a\u00a0<a href=\"https:\/\/psychnews.psychiatryonline.org\/doi\/full\/10.1176\/pn.37.3.0019\" target=\"_blank\" rel=\"noopener\">black box warning<\/a>\u00a0on the label for Serzone. The warning had to include that patients taking Serzone can develop severe and possibly life-threatening\u00a0<a href=\"https:\/\/ajp.psychiatryonline.org\/doi\/full\/10.1176\/appi.ajp.2013.13050709\" target=\"_blank\" rel=\"noopener\">liver problems<\/a>.<\/p>\n<p>In March 2002, the FDA cautioned the public that patients reported cases of life-threatening liver failure. There were over 109 cases, and in at least 23 of the cases, patients experienced liver failure.<\/p>\n<p>Sixteen other patients underwent liver transplants or died. The FDA estimated that liver failure rates for Serzone patients were three to four times greater than for non-users.<\/p>\n<p>In March 2003, the consumer group\u00a0<a href=\"https:\/\/www.citizen.org\/article\/supplement-to-petition-to-ban-antidepressant-drug-nefazadone-serzone\" target=\"_blank\" rel=\"noopener\">Public Citizen<\/a>\u00a0petitioned the FDA to ban Serzone from the U.S. market. The group cited the number of liver toxicity deaths purportedly related to the antidepressant.<\/p>\n<p>Bristol Myer Squibb removed Serzone from the U.S. market in 2004. They did so after many claims of liver dysfunction after taking Serzone.<\/p>\n<h2>Serious Risks: Increased Depression and Suicidal Impulses<\/h2>\n<p>Antidepressant medications, including Serzone, came under scrutiny from the FDA. Studies and clinical trials have found that antidepressants can increase depression severity. It can also cause suicidal impulses in some patients.<\/p>\n<p>In 2004, the FDA instructed manufacturers to include a &#8220;<a href=\"https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/warnings-and-precautions-contraindications-and-boxed-warning-sections-labeling-human-prescription\" target=\"_blank\" rel=\"noopener\">boxed warning<\/a>&#8221; on the labels of antidepressant drugs. This boxed warning informs patients about the risk of suicidal behavior in children and adolescents.<\/p>\n<h2>Talk to Your Healthcare Provider Before Taking Nefazodone<\/h2>\n<p>You should never start an antidepressant without talking to your doctor. There are certain things they must know to help you avoid <a href=\"https:\/\/www.webmd.com\/interaction-checker\/default.htm\" target=\"_blank\" rel=\"noopener\">adverse drug interactions<\/a>.<\/p>\n<p>When considering taking nefazodone or any antidepressant, tell your healthcare provider if you have any of the following:<\/p>\n<ul>\n<li>Heart disease<\/li>\n<li>High or low blood pressure<\/li>\n<li>Irregular heartbeat<\/li>\n<li>Seizures<\/li>\n<li>Past or present manic episodes<\/li>\n<li>Kidney disease<\/li>\n<li>Liver disease<\/li>\n<li>Are pregnant or breastfeeding<\/li>\n<\/ul>\n<p>Also, let your doctor know if you&#8217;re currently taking other antidepressants or medications. This includes vitamins and supplements. If you&#8217;re a caregiver for a loved one with depression, tell your family member&#8217;s doctor what medications they&#8217;re taking.<\/p>\n<h2>What To Do if You&#8217;re Hurt After Taking Serzone<\/h2>\n<p>If you or your loved one develops an illness after taking nefazodone, seek immediate medical attention. You should also speak with an experienced product liability attorney.<\/p>\n<p>Depending on the facts of your case, you may have a legal\u00a0<a href=\"https:\/\/www.findlaw.com\/hirealawyer\/choosing-the-right-lawyer\/drugs-and-medical-devices.html\">claim against the drug manufacturer<\/a>. All drugmakers have a legal duty to make their products as safe as possible. They must also notify prescribers and the public of the risks of their drugs.<\/p>\n<p>If the pharmaceutical company doesn&#8217;t do this, the court may hold them liable for your injuries.<\/p>\n<p>You may also have a claim against your doctor for\u00a0<a href=\"https:\/\/www.findlaw.com\/injury\/medical-malpractice\/medical-malpractice-liability.html\">medical malpractice<\/a>. For example, if your doctor didn&#8217;t tell you about nefazodone&#8217;s side effects and risks, you may be able to sue them.<\/p>\n<p>Regardless of which type of lawsuit you file, your personal injury lawyer will demand the following <a href=\"https:\/\/www.findlaw.com\/injury\/accident-injury-law\/injury-damages.html\">injury damages<\/a>:<\/p>\n<ul>\n<li>Medical bills and future medical expenses<\/li>\n<li>Lost wages and lost future income<\/li>\n<li>Pain and suffering<\/li>\n<li>Punitive damages (in limited cases)<\/li>\n<li>Burial and funeral expenses (in wrongful death lawsuits)<\/li>\n<\/ul>\n<p>Your compensation will depend on the nature and severity of your injuries.<\/p>\n<h2>Contact an Attorney for Legal Help<\/h2>\n<p>Serzone has been off the market for over 20 years. However, generic versions are still available today. While you may have missed the <a href=\"https:\/\/www.findlaw.com\/state\/statutes-of-limitations.html\">statute of limitations<\/a> period to sue the drug manufacturer, you might still have legal options depending on the facts of your case. An attorney can review your situation and determine if you are able to take legal action.<\/p>\n<p>FindLaw&#8217;s <a href=\"https:\/\/lawyers.findlaw.com\/products-liability-law\/?fli=dcta\" target=\"_blank\" rel=\"noopener\">attorney directory<\/a> can connect you to qualified product liability lawyers in your area. Select your state or city to review contact and ratings information for local experts. Your search results will also link you to additional details about the attorneys\u2019 experience with pharmaceutical cases. Many attorneys offer free case evaluations.<\/p>\n\n\n<div class=\"was-this-helpful\">\n    <div\n            class=\"was-this-helpful__question-container\"\n            aria-labelledby=\"was-this-helpful__question\"\n            role=\"group\"\n    >\n        <span\n                id=\"was-this-helpful__question\"\n                class=\"was-this-helpful__question fl-text-lg-bold\"\n        >Was this helpful?<\/span>\n        <button\n                class=\"was-this-helpful__button fl-text-sm\"\n                aria-label=\"Yes\"\n                value=\"yes\"\n        >\n            <span class=\"was-this-helpful__button-text fl-text-bold\">Yes<\/span>\n            <i class=\"was-this-helpful__button-icon\">\n                <svg width=\"22\" height=\"22\" viewBox=\"0 0 22 22\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                    <g id=\"thumbs-up\" clip-path=\"url(#clip0_604_3418)\">\n                        <path id=\"Vector\"\n                            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     <\/div>\n    <\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Serzone was discontinued in 2004 but generic versions are still available. Learn about its health risks, side effects, and your legal options at FindLaw.<\/p>\n","protected":false},"author":41135,"featured_media":0,"parent":353191,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"app\/Http\/Controllers\/Templates\/ArticleWithBreadcrumbsController.php","meta":{"_acf_changed":false,"_stopmodifiedupdate":true,"_modified_date":"","_autodraft_ids":[],"_cloudinary_featured_overwrite":false,"_sb_is_suggestion_mode":false,"_sb_show_suggestion_boards":false,"_sb_show_comment_boards":false,"_sb_suggestion_history":"","_sb_update_block_changes":"","_is_real_time_mode":false,"_realtime_collaborators":"","footnotes":"","cf_checklist_status":[]},"categories":[2734],"tags":[],"state_laws_tags":[],"flmsa":[],"class_list":["post-353364","page","type-page","status-publish","hentry","category-injury"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/pages\/353364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/users\/41135"}],"replies":[{"embeddable":true,"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/comments?post=353364"}],"version-history":[{"count":0,"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/pages\/353364\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/pages\/353191"}],"wp:attachment":[{"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/media?parent=353364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/categories?post=353364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/tags?post=353364"},{"taxonomy":"state_laws_tags","embeddable":true,"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/state_laws_tags?post=353364"},{"taxonomy":"flmsa","embeddable":true,"href":"https:\/\/www.findlaw.com\/law-api\/wp-json\/wp\/v2\/flmsa?post=353364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}