{"id":353409,"date":"2016-04-04T10:46:56","date_gmt":"2016-04-04T15:46:56","guid":{"rendered":"https:\/\/content.findlaw-admin.com\/ability-law\/injury\/product-liability\/zyprexa-recent-news.html"},"modified":"2024-02-20T12:48:34","modified_gmt":"2024-02-20T17:48:34","slug":"zyprexa-recent-news","status":"publish","type":"page","link":"https:\/\/www.findlaw.com\/injury\/product-liability\/zyprexa-recent-news.html","title":{"rendered":"Zyprexa: News and Research"},"content":{"rendered":"\n<div class=\"wp-container-core-columns-is-layout-9d6595d7 fl-sectionWithSidebar fl-container fl-flex fl-flex-wrap fl-gap30\">\n<div class=\"fl-page-articles fl-section-main fl-section-main-full-width\"><h1 class=\"fl-no-margin-top\">Zyprexa: News and Research<\/h1>\n\n<section class=\"fl-gutenberg-byline\">\n    <div class=\"fl-gutenberg-byline-content\">\n                    By <a href=\"https:\/\/www.findlaw.com\/company\/our-team\/christie-nicholson-j-d\/\">Christie Nicholson, J.D.<\/a> | Legally reviewed by <a\n                href=\"https:\/\/www.findlaw.com\/company\/our-team\/oni-harton-j-d\/\">Oni Harton, J.D.<\/a>\n                | Last updated\n        <time>\n                            February 20, 2024\n                    <\/time>\n    <\/div>\n\n    \n    <details class=\"fl-gutenberg-byline-toggle fl-gutenberg-byline-legally-reviewed\">\n        <summary>\n            <i class=\"fl-gutenberg-byline-icon\" aria-hidden=\"true\"><\/i>\n            Legally Reviewed\n        <\/summary>\n\n        <div class=\"fl-gutenberg-byline-toggle-content\">\n            <p><em>This article has been written and reviewed for legal accuracy, clarity, and style by <a href=\"https:\/\/www.findlaw.com\/company\/our-team.html\">FindLaw\u2019s team of legal writers and attorneys<\/a> and in accordance with <a href=\"https:\/\/www.findlaw.com\/company\/company-history\/editorial-policy.html\">our editorial standards<\/a>.<\/em><\/p>\n\n        <\/div>\n    <\/details>\n\n    <details class=\"fl-gutenberg-byline-toggle fl-gutenberg-byline-fast-checked\">\n        <summary>\n            <i class=\"fl-gutenberg-byline-icon\" aria-hidden=\"true\"><\/i>\n            Fact-Checked\n        <\/summary>\n\n        <div class=\"fl-gutenberg-byline-toggle-content\">\n            <p><em>The last updated date refers to the last time this article was reviewed by FindLaw or one of our <a href=\"https:\/\/www.findlaw.com\/company\/our-team\/contributing-authors.html\">contributing authors<\/a>. We make every effort to keep our articles updated. For information regarding a specific legal issue affecting you, please <a href=\"https:\/\/lawyers.findlaw.com\/?fli=bylinelink\" target=\"_blank\" rel=\"noopener\">contact an attorney in your area<\/a>.<\/em><\/p>\n\n        <\/div>\n    <\/details>\n<\/section>\n\n\n<div class=\"fl-key-takeaways fl-mb30\" data-testid=\"fl-key-takeaways\">\n    <div class=\"fl-card-content\">\n        <div class=\"fl-card-body fl-card-bg-teal fl-flex fl-flex-column\">\n                            <h2 class=\"fl-card-title fl-h2 fl-no-margin\">Key Takeaways<\/h2>\n                        <p>Zyprexa is prescribed to treat schizophrenia and bipolar disorder. While effective, it has been linked to serious side effects such as weight gain, hyperglycemia, and increased risk of death in elderly dementia patients. Eli Lilly faced lawsuits for promoting Zyprexa for unapproved uses and allegedly concealing known health risks.<\/p>\n\n        <\/div>\n    <\/div>\n<\/div>\n\n\n<p>Zyprexa\u00a0(olanzapine) is an atypical antipsychotic drug that treats schizophrenia. Eli Lilly and Company manufactures and sells <a href=\"https:\/\/www.findlaw.com\/injury\/product-liability\/zyprexa.html\">Zyprexa<\/a>. The U.S. Food and Drug Administration (FDA) approved the drug in 1996. Since its approval, healthcare providers have prescribed this drug to millions of patients.<\/p>\n<p>Clinicians also prescribe Zyprexa for the treatment of bipolar disorder in patients suffering from manic episodes. The FDA fact sheet indicates that adults and adolescents can take the drug. The\u00a0<a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2014\/020592s062021086s040021253s048lbl.pdf\" target=\"_blank\" rel=\"noopener\">FDA fact sheet<\/a>\u00a0also warns of Zyprexa&#8217;s other side effects.<\/p>\n<p>Adverse events of the antipsychotic drug Zyprexa include the following:<\/p>\n<ul>\n<li>Weight gain<\/li>\n<li>Increased risk of hyperglycemia<\/li>\n<li>Increased risk of suicide<\/li>\n<li>Higher incidence of death in elderly patients suffering from dementia<\/li>\n<li>Tardive dyskinesia<\/li>\n<\/ul>\n<p>Zyprexa clinical trials have confirmed the above side effects. There have also been legal claims against the Indianapolis-based drugmaker Eli Lilly for promoting unapproved uses of the drug.<\/p>\n<p>This article discusses Zyprexa news and litigation. If you&#8217;ve developed an illness after using Zyprexa, contact a <a href=\"https:\/\/lawyers.findlaw.com\/products-liability-law\/\" target=\"_blank\" rel=\"noopener\">product liability attorney<\/a> near you for personalized legal advice. An attorney can determine if you have a valid claim and guide you through the legal process.<\/p>\n<h2>Internal Eli Lilly Documents Posted Online<\/h2>\n<p>In February 2007, Eli Lilly <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1767295\/\" target=\"_blank\" rel=\"noopener\">filed for an injunction<\/a> in New York federal court to prevent internal documents from being posted online. An injunction is a legal order prohibiting a person from engaging in a particular behavior.<\/p>\n<p>A former employee allegedly wanted to post copies of internal documents regarding the drugmaker&#8217;s marketing of Zyprexa for off-label uses.<\/p>\n<p>These documents also showed that the drug manufacturer concealed evidence that Zyprexa caused:<\/p>\n<ul>\n<li>Weight gain<\/li>\n<li>Diabetes<\/li>\n<li>Hyperglycemia<\/li>\n<li>Cardiovascular disease<\/li>\n<\/ul>\n<p>The Eastern District of New York\u00a0<a href=\"https:\/\/ahrp.org\/court-ruling-injunction-on-release-of-zyprexa-documents\/\" target=\"_blank\" rel=\"noopener\">rejected Eli Lily &amp; Co.&#8217;s request for an injunction<\/a>. The judge said trying to prevent someone from posting this information on the internet would be pointless. He also held that there was no First Amendment right to protect these documents.<\/p>\n<h2>Eli Lilly Settles Lawsuits for Off-Label Uses of Zyprexa<\/h2>\n<p>On January 15, 2009, the Justice Department announced that it had settled <a href=\"https:\/\/www.findlaw.com\/injury\/product-liability\/pharmaceutical-drug-liability.html\">multiple claims against the manufacturer<\/a> of Zyprexa. The federal and state governments sued Eli Lilly for fraudulent marketing of its antipsychotic drug and for submitting fraudulent healthcare claims.<\/p>\n<p>The drugmaker marketed the drug to long-term care facilities for off-label uses. Specifically, the company trained its sales staff to convince doctors to prescribe the drug for the following:<\/p>\n<ul>\n<li>Hostility and aggression<\/li>\n<li>Generalized sleep disorders<\/li>\n<li>Dementia<\/li>\n<li>Alzheimer&#8217;s<\/li>\n<li>Depression<\/li>\n<li>Mood disorders<\/li>\n<\/ul>\n<p>The company knew the FDA hadn&#8217;t approved Zyprexa for these uses. The\u00a0<a href=\"https:\/\/www.fda.gov\/regulatory-information\/laws-enforced-fda\/federal-food-drug-and-cosmetic-act-fdc-act\" target=\"_blank\" rel=\"noopener\">Food, Drug, and Cosmetic Act<\/a>\u00a0forbids drug manufacturers from marketing their products for off-label uses. Unless the FDA specifically approves a drug for off-label use, drugmakers must refrain from promoting off-label use of Zyprexa.<\/p>\n<p>The federal government and state attorneys general sued Eli Lilly and Company in the U.S. District Court for the\u00a0<a href=\"https:\/\/www.justice.gov\/opa\/pr\/eli-lilly-and-company-agrees-pay-1415-billion-resolve-allegations-label-promotion-zyprexa\" target=\"_blank\" rel=\"noopener\">Eastern District of Pennsylvania.<\/a>\u00a0In January 2009, the parties settled the claims for more than $1.4 billion. The agreement was for Eli Lilly to pay more than $800 million in civil damages and another $515 million in criminal fines.<\/p>\n<h2>Class Action Lawsuit for Patient Deaths<\/h2>\n<p>In June 2013, the FDA reported that it was investigating the\u00a0<a href=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-drug-safety-communication-fda-review-study-sheds-light-two-deaths-associated-injectable\" target=\"_blank\" rel=\"noopener\">death of two Zyprexa patients<\/a>\u00a0who died within hours of taking the drug. Both patients suffered from post-injection delirium\/sedation syndrome (PDSS). This is a condition where a drug sedates a patient to the point where they lapse into a coma.<\/p>\n<p>A small number of people who experience PDSS never regain consciousness. This was the case for two Zyprexa patients. In 2015, the New York Times reported that the FDA had closed its investigation into the deaths. This was good news for the drug manufacturer but bad news for the victims&#8217; family members. The\u00a0<a href=\"https:\/\/caselaw.findlaw.com\/court\/us-2nd-circuit\/1519924.html\" target=\"_blank\" rel=\"noopener\">Zyprexa products liability litigation<\/a>\u00a0also came to an end.<\/p>\n<h2>FDA Warns About Rare Skin Rash<\/h2>\n<p>In May 2016, the FDA ordered Eli Lilly &amp; Co. to change the label to warn about a rare but serious skin condition called DRESS. According to the FDA, patients taking Zyprexa and other olanzapine-containing products were at an increased risk of developing this skin disease.<\/p>\n<p><a href=\"https:\/\/www.osmosis.org\/answers\/dress-syndrome\" target=\"_blank\" rel=\"noopener\">Drug reaction of eosinophilia and systemic symptoms<\/a>\u00a0(DRESS) is a dangerous skin rash that spreads throughout your body. Patients who notice a fever with a rash should seek immediate medication attention. Patients with DRESS may also notice swelling around the face and neck.<\/p>\n<p>Prescribing physicians must warn patients of this risk. The drugmaker&#8217;s package insert should include information about this side effect as well.<\/p>\n<h2>Study Shows Zyprexa More Effective in the Long-Term<\/h2>\n<p>In 2019, the journal\u00a0<i><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6733343\/\" target=\"_blank\" rel=\"noopener\">Neuropsychiatry Disorder Treatment<\/a><\/i>\u00a0published a study on the effectiveness of Zyprexa. According to this study, many clinicians prescribe olanzapine to patients with schizophrenia. It doesn&#8217;t require constant blood monitoring. But one of the major side effects of Zyprexa is weight gain.<\/p>\n<p>Clinicians often have trouble convincing patients to continue taking antipsychotics that make them gain weight. Researchers investigated whether this side effect impacted the long-term use of olanzapine. Specifically, this study evaluated the &#8220;time to relapse&#8221; rate of Zyprexa compared to Haldol.<\/p>\n<p>The study found that while Zyprexa is a second-choice antipsychotic medication, it has long-term effectiveness. The time-to-relapse rate for Zyprexa was only 20% compared to 28% for Haldol.<\/p>\n<h2>FDA Approves New Combination Atypical Antipsychotic Drug<\/h2>\n<p>In June 2021, the FDA approved a new atypical antipsychotic drug. Alkermes plc&#8217;s prescription medication,\u00a0<a href=\"https:\/\/www.psychiatrictimes.com\/view\/fda-approves-new-atypical-antipsychotic-less-adverse-effects\" target=\"_blank\" rel=\"noopener\">Lybalvi<\/a>, combines olanzapine and samidorphan. The new medication had fewer side effects than most antipsychotics. Another benefit of Lybalvi is that it doesn&#8217;t cause weight gain like Zyprexa.<\/p>\n<p>According to the FDA, doctors often give Lybalvi to patients taking lithium or valproate. Doctors prescribe this new drug to treat schizophrenia or bipolar I disorder. <a href=\"https:\/\/www.webmd.com\/drugs\/2\/drug-181659\/lybalvi-oral\/details\" target=\"_blank\" rel=\"noopener\">Lybalvi<\/a> helps treat acute manic and mixed episodes.<\/p>\n<h2>An Attorney Can Help With Your Zyprexa Lawsuit<\/h2>\n<p>If you or your loved one develops a serious illness after taking Zyprexa or olanzapine, seek immediate medical attention. Then, consider contacting a lawyer. Depending on the facts of your case, you may be able to file a lawsuit against the drug manufacturer for <a href=\"https:\/\/www.findlaw.com\/injury\/product-liability.html\">product liability claims<\/a>.\u00a0<\/p>\n<p>FindLaw&#8217;s directory of <a href=\"https:\/\/lawyers.findlaw.com\/drugs-medical-devices\/?fli=dcta\" target=\"_blank\" rel=\"noopener\">product liability attorneys<\/a> can get you started. Select your state or city to review contact and ratings information for local experts. Your search results will also link you to additional details about the attorneys\u2019 experience with dangerous drug cases. Many law offices offer free consultations.<\/p>\n\n\n<div class=\"was-this-helpful\">\n    <div\n            class=\"was-this-helpful__question-container\"\n            aria-labelledby=\"was-this-helpful__question\"\n            role=\"group\"\n    >\n        <span\n                id=\"was-this-helpful__question\"\n                class=\"was-this-helpful__question fl-text-lg-bold\"\n        >Was this helpful?<\/span>\n        <button\n                class=\"was-this-helpful__button fl-text-sm\"\n                aria-label=\"Yes\"\n                value=\"yes\"\n        >\n            <span class=\"was-this-helpful__button-text fl-text-bold\">Yes<\/span>\n            <i class=\"was-this-helpful__button-icon\">\n                <svg width=\"22\" height=\"22\" viewBox=\"0 0 22 22\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                    <g id=\"thumbs-up\" clip-path=\"url(#clip0_604_3418)\">\n                        <path id=\"Vector\"\n                             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1.78839 2.79235 2.22309 2.72003 2.7L1.34003 11.7C1.29652 11.9866 1.31586 12.2793 1.39669 12.5577C1.47753 12.8362 1.61793 13.0937 1.80817 13.3125C1.99842 13.5313 2.23395 13.7061 2.49846 13.8248C2.76297 13.9435 3.05012 14.0033 3.34003 14H9.00003Z\"\n                              stroke=\"#666666\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/>\n                    <\/g>\n                    <defs>\n                        <clipPath id=\"clip0_604_3423\">\n                            <rect width=\"22\" height=\"22\" fill=\"white\"\/>\n                        <\/clipPath>\n                    <\/defs>\n                <\/svg>\n            <\/i>\n        <\/button>\n    <\/div>\n    <span class=\"was-this-helpful__taken-action fl-text-sm-bold\"><\/span>\n    <div class=\"was-this-helpful__feedback-container\">\n        <div class=\"was-this-helpful__choose-option-message\" role=\"status\">\n            <p 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class=\"fl-editors-summary\" data-testid=\"fl-editors-summary\">\n    \n    <div class=\"fl-editors-summary-content\" data-testid=\"fl-editors-summary-content\">\n                    <h2>Can I Solve This on My Own or Do I Need an Attorney?<\/h2>\n                <div class=\"fl-editors-summary-content-main\" data-testid=\"fl-editors-summary-content-main\">\n            \n        <\/div>\n        <ul class=\"fl-list-style-none\">\n                            <li data-testid=\"fl-editors-summary-content-item\">\n                    <i class=\"fa fa-check medium fl-editors-summary-content-item-icon\" aria-hidden=\"true\"><\/i>\n                    A lawyer can help seek fair compensation on your behalf\n\n                <\/li>\n                            <li data-testid=\"fl-editors-summary-content-item\">\n                    <i class=\"fa fa-check medium fl-editors-summary-content-item-icon\" aria-hidden=\"true\"><\/i>\n                    Drug manufacturers have teams of lawyers on 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